BLNK (B-cell linker)

Identification of CMTM7 as a Transmembrane Linker of BLNK and the B-Cell Receptor

BLNK is a pivotal adaptor protein in the signal transduction pathway from the IgM class B-cell receptor. BLNK is phosphorylated by Syk and binds various signaling intermediates, leading to cellular events including MAP-kinase activation, culminating in cellular activation. It remains unclear how BLNK is initially recruited to the surface IgM (sIgM) complex to which Syk is also recruited. Here w...

Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins.

Persistent Rel/nuclear factor-kappaB (NF-kappaB) activity is a hallmark of many human cancers, and the Rel proteins are implicated in leukemia/lymphomagenesis but the mechanism is not fully understood. Microarray analysis to identify transformation-impacting genes regulated by NF-kappaB's oncogenic v-Rel and c-Rel proteins uncovered that Rel protein expression leads to transcriptional repressio...

Lymphocyte Transformation by Rel Proteins Phosphoinositide 3-Kinase (BCAP) Is Important for Repression of B-Cell Linker (BLNK) and B-Cell Adaptor for Updated Version

Persistent Rel/nuclear factor-KB (NF-KB) activity is a hallmark of many human cancers, and the Rel proteins are implicated in leukemia/lymphomagenesis but the mechanism is not fully understood. Microarray analysis to identify transformationimpacting genes regulated by NF-KB’s oncogenic v-Rel and c-Rel proteins uncovered that Rel protein expression leads to transcriptional repression of key B-ce...

B and T lymphocyte attenuator regulates B cell receptor signaling by targeting Syk and BLNK.

B and T lymphocyte attenuator (BTLA) functions as a negative regulator of T cell activation and proliferation. Although the role of BTLA in regulating T cell responses has been characterized, a thorough investigation into the precise molecular mechanisms involved in BTLA-mediated lymphocyte attenuation and, more specifically, its role in regulating B cell activation has not been presented. In t...

Cell Acute Lymphoblastic Leukemia B Transcription by PU.1 and Spi-B in Murine Regulation of B Cell Linker Protein